Plasgene has developed proprietary methods for the selective removal or curing of DNA plasmids from bacteria. These methods, based on the company’s pCURE™ technology, overcome many of the difficulties which are associated with the displacement of plasmids from bacteria.


  • For elimination of F-like plasmids from enteric bacteria.
  • No host stress during displacement.
  • Kit contains easy to follow protocol with the necessary components for plasmid elimination and diagnosis of removal.

To purchase pCURE2, or for any enquiries, please contact Prof. Chris Thomas.

This kit uses the plasmid, pCURE2, which interferes with the replication and population maintenance functions of F-like plasmids, in Escherichia coli and other bacteria of the Enterobacteriaceae. By interfering with both F-plasmid replication and post-segregational killing systems, the kit offers a way of eliminating these plasmids without stressing the host bacterium.

For further information, please access the pCURE2 instruction manual or our free BioTechniques journal article.